Transcriptomics

Dataset Information

0

Cell type-dependent control of enhancer and p53 transcriptional activity by p63


ABSTRACT: In this work, we demonstrate that the p53-induced transcriptome is dependent on pre-establishment of cell type-dependent cis-regulatory networks. The epithelial-specific p53 transcriptome is strongly dependent on p63, which acts as a pioneer factor for epithelial-specific enhancers. These results suggest a broad mechanism for regulating the p53-dependent cellular response to stress through differential regulation of cis-regulatory elements and identify p63 as a direct and critical regulator of enhancer activity in epithelial cell types.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE111009 | GEO | 2019/02/11

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2010-11-23 | E-GEOD-25524 | biostudies-arrayexpress
2010-11-23 | GSE25524 | GEO
2010-08-15 | E-GEOD-17611 | biostudies-arrayexpress
2010-08-15 | GSE17611 | GEO
2006-07-08 | GSE5229 | GEO
2023-07-31 | PXD029596 | Pride
| PRJNA435584 | ENA
2006-12-01 | GSE6132 | GEO
2006-06-06 | GSE4975 | GEO
2010-03-12 | GSE20286 | GEO