Genome-wide maps of TBX1 state in transfected BCPAP cells
Ontology highlight
ABSTRACT: Genome wide identification of TBX1 sites of occupancy in thyroid cancer cell line BCPAP cells by comparing control BCPAP cells transfected with pcDNA3.1-Vector (cotains Myc tag) with cells transfected with pcDNA3.1-TBX1 (contains Myc tag). By obtaining over 30 Million bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide chromatin-state maps of TBX1 transfected. We find that transcription factor TBX1 exerts tumor suppressive properties through regulating multiple downstream targets involved in PI3K/Akt and MAPK/Erk signaling pathways.
ORGANISM(S): Homo sapiens
PROVIDER: GSE111072 | GEO | 2018/05/01
REPOSITORIES: GEO
ACCESS DATA