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Human Transcriptome Array 2.0 (HTA) from SW480 colon adenocarcinoma cells transfected with LINC00152 Stealth siRNAs or Stealth Negative Control Medium GC siRNAs

ABSTRACT: Whole transcriptome expression levels of SW480 colon adenocarcinoma cells transfected with LINC00152 Stealth siRNAs or Stealth Negative Control Medium GC siRNAs, analyzed by HTA 2.0 microarrays

ORGANISM(S): Homo sapiens

PROVIDER: GSE111413 | GEO | 2020/03/04

REPOSITORIES: GEO

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Human Transcriptome Array 2.0 (HTA) from SW480 colon adenocarcinoma cells transfected with LINC00152 Stealth siRNAs or Stealth Negative Control Medium GC siRNAs

Project description:Human Transcriptome Array 2.0 (HTA) from SW480 colon adenocarcinoma cells transfected with LINC00152 Stealth siRNAs or Stealth Negative Control Medium GC siRNAs

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Frozen bone marrow (BM) samples belonging to pediatric acute myeloid leukemia (AML) cohort analyzed by Human Transcriptome Array 2.0 (HTA 2.0)

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High-throughput RNA sequencing analysis of human colon cancer cell line HCT116 transfected with LINC00152 siRNA.

Project description:Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are using RNA sequencing analysis to evaluate the effects of si-LINC00152 on the mRNA of human colon cancer cell line HCT116. Methods: Human colon cancer cell line HCT116 was transfected with a control non-targeting siRNA to cells or transfected with siRNA targeting LINC00152 for 36 hours in DMEM medium (with 10% serum). Total RNA were extracted and detected by Illumina high-throughput RNA sequencing data analysis. 2 independent biological replicates were plated, transfected in parallel for each control and siRNA. Results: Log-fold changes of up- or down-regulated mRNAs between the control and experiment group were selected with a significance threshold of p<0.05. There are 90 mRNAs were up-regulated and 159 were down-regulated in “si-LINC00152” group comparing to “control” group. Conclusions: Our study describes the mRNA changes of human colon cancer cell line HCT116 transfected with LINC00152 siRNA.

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