Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Loss of TET2 results in DNA methylation changes in mouse GC B-cells (Bisulfite-Seq data set)

ABSTRACT: Absence of Tet2 at mouse cells results in gain of DNA methylation

ORGANISM(S): Mus musculus

PROVIDER: GSE111698 | GEO | 2018/10/08

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Loss of TET2 results in DNA methylation changes in mouse GC B-cells (hMeDIP-Seq data set)

Project description:Absence of Tet2 at mouse cells results in loss of hydroxymethylcytosine

2018-10-08 | GSE111699 | GEO

Loss of TET2 results in DNA methylation changes in mouse naïve B-cells

Project description:Absence of Tet2 at mouse cells results in gain of DNA methylation

2020-06-29 | GSE132595 | GEO

Loss of TET2 results in gene expression represssion in mouse GC B-cells and lymphoma cells (RNA-Seq data set)

Project description:Absence of Tet2 at mouse cells results in reduced gene expression

2018-10-08 | GSE111697 | GEO

Loss of TET2 results in DNA methylation changes in mouse GC B-cells (Bisulfite-Seq data set)

Project description:Loss of TET2 results in DNA methylation changes in mouse GC B-cells (Bisulfite-Seq data set)

| PRJNA438029 | ENA

Loss of TET2 results in gene expression represssion in mouse naïve B-cells and lymphoma cells [RNA-seq]

Project description:Absence of Tet2 at mouse cells results in reduced gene expression

2020-06-29 | GSE132596 | GEO

Loss of TET2 results in gene expression represssion in mouse naïve B-cells and lymphoma cells [DNA-Seq]

Project description:Absence of Tet2 at mouse cells does not result in decreased somatic hypermutation

2020-06-29 | GSE140085 | GEO

Concomitant loss of TET2 and TET3 results in T cell expansion and genomic instability

Project description:TET proteins are tumor suppressors that through their catalytic activity oxidize 5-methylcytosine to 5-hydroxymethylcytosine, to promote DNA demethylation and to regulate gene expression. Notably, TET2 is the second most frequently mutated gene in hematological malignancies, including T cell lymphomas. However, murine models with deletion of TET2 do not exhibit T cell expansion, presumably due to redundancy with other members of the TET family of proteins. In order to gain insight on the TET mediated molecular events that safeguard T cells from aberrant proliferation we performed serial adoptive transfers of murine CD4 T cells that lack concomitantly TET2 and TET3 to fully immunocompetent congenic mice. Our data reveal a progressive acquisition of malignant traits upon loss of TET2 and TET3 that is characterized by loss of genomic integrity, acquisition of aneuploidy and upregulation of the protooncogene Myc.

2024-11-11 | GSE278239 | GEO

Loss of TET2 results in DNA methylation changes in mouse GC B-cells

Project description:Loss of TET2 results in DNA methylation changes in mouse GC B-cells

| PRJNA437909 | ENA

Concomitant loss of TET2 and TET3 results in T cell expansion and genomic instability [WGS]

Project description:TET proteins are tumor suppressors that through their catalytic activity oxidize 5-methylcytosine to 5-hydroxymethylcytosine, to promote DNA demethylation and to regulate gene expression. Notably, TET2 is one of the most frequently mutated genes in hematological malignancies, including T cell lymphomas. However, murine models with deletion of TET2 do not exhibit T cell expansion, presumably due to redundancy with other members of the TET family of proteins. In order to gain insight on the TET mediated molecular events that safeguard T cells from aberrant proliferation we performed serial adoptive transfers of murine CD4 T cells that lack concomitantly TET2 and TET3 to fully immunocompetent congenic mice. Our data reveal a progressive acquisition of malignant traits upon loss of TET2 and TET3 that is characterized by loss of genomic integrity, acquisition of aneuploidy and upregulation of the protooncogene Myc.

2024-11-07 | GSE276581 | GEO

Loss of TET2 results in DNA methylation changes in mouse GC B-cells (hMeDIP-Seq data set)

Project description:Loss of TET2 results in DNA methylation changes in mouse GC B-cells (hMeDIP-Seq data set)

| PRJNA438028 | ENA