Genomics

Dataset Information

0

RUNX1 mutations lead to a myeloid differentiation block by altering the RUNX1 transcriptional program (ChIP-Seq)


ABSTRACT: Mutations in the RUNX1 gene (RUNX1mut) have been established in myelodysplasia (MDS), de novo and secondary acute myeloid leukaemia (AML), and are in general associated with an unfavourable clinical outcome. Familial RUNX1 mutations are associated with familial thrombocytopenia and these patients have a predisposition to AML development. However, a number of studies have been performed so far in mice which might be distinct from the human hematopoietic system. Therefore we studied the cellular phenotypes, the RUNX1 binding pattern and expression profile induced by RUNX1mut in cord blood (CB) CD34+ cells and induced pluripotent stem cell (iPSC) and compared these findings to primary RUNX1mut AML’s.

ORGANISM(S): Homo sapiens

PROVIDER: GSE111917 | GEO | 2019/02/06

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2019-02-06 | GSE111918 | GEO
2014-07-01 | E-GEOD-54295 | biostudies-arrayexpress
2010-09-11 | E-TABM-792 | biostudies-arrayexpress
2014-07-01 | GSE54295 | GEO
2013-03-22 | E-GEOD-45373 | biostudies-arrayexpress
2013-03-22 | E-GEOD-45372 | biostudies-arrayexpress
2013-03-22 | GSE45373 | GEO
2013-03-22 | GSE45372 | GEO
| PRJNA438536 | ENA
2017-07-05 | E-MTAB-4679 | biostudies-arrayexpress