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Novel risk variants affecting enhancers of TH1 and TREG cells in type 1 diabetes [ChIP-seq]

ABSTRACT: Most type 1 diabets (T1D) associated SNPs are located in non-coding regions, making it hard to understand their functional impact. We performed epigenomic profiling of two enhancer marks, H3K4me1 and H3K27ac, using primary TH1 and TREG cells from healthy and T1D subjects. By integrating enhancers predicted using these ChIP-Seq data, T1D associated SNPs and additional supporting data, we found and validated several novel risk SNPs for T1D.

ORGANISM(S): Homo sapiens

PROVIDER: GSE112337 | GEO | 2019/03/26

REPOSITORIES: GEO

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