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Keap1-dependent gene expression determined in the liver using conditional Keap1 knockout mice vs. genetic control mice

ABSTRACT: To compare hepatic gene expression in conditional Keap1 knockout (Alb-Cre:Keap1(flox/-)) and genetic control mice. Disruption of Keap1-mediated repression of Nrf2 signaling was expected to result in increased expression of Nrf2-regulated genes. Keywords: comparative expression profiling

ORGANISM(S): Mus musculus

PROVIDER: GSE11287 | GEO | 2008/05/01

SECONDARY ACCESSION(S): PRJNA106699

REPOSITORIES: GEO

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Transcription profiling of mouse liver from conditional Keap1 knockout mice vs. genetic control mice

Project description:To compare hepatic gene expression in conditional Keap1 knockout (Alb-Cre:Keap1(flox/-)) and genetic control mice. Disruption of Keap1-mediated repression of Nrf2 signaling was expected to result in increased expression of Nrf2-regulated genes. Experiment Overall Design: Hepatic gene expression was compared in conditional Keap1 knockout and genetic control mice (Alb-Cre:Keap1(flox/+)) mice. Male 9 week old mice were used, n=3/group.

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