Methylation profiling

Dataset Information

0

Edematous Severe Acute Malnutrition is Characterized by Hypomethylation of DNA


ABSTRACT: A slower transmethylation of one-carbon substrates in the edematous form of severe acute malnutrition (ESAM) suggests that downstream aberrations in DNA methylation could drive differences in acute pathogenesis between ESAM and non-edematous malnutrition (NESAM). Here, we integrate genome-wide assessments of DNA methylation with corresponding gene expression profiles and sequence variation to show that relative to NESAM, acute ESAM is characterized by significant hypomethylation at 99% of differentially methylated loci in two SAM cohorts, whereas recovered adults show no significant differences in methylation. Hypomethylated loci correlate with both up- and down-regulation of proximal genes, which are associated with the clinical sub-phenotypes of kwashiorkor and enriched for GWAS hits linked to over-nutrition, including fatty liver and diabetes. Methylation at these loci also appears to be influenced by nearby genetic variation in a manner that varies with nutritional status. Our findings implicate epigenetic and genetic variation in ESAM pathophysiology and support methyl-group supplementation in ESAM management.

ORGANISM(S): Homo sapiens

PROVIDER: GSE112893 | GEO | 2019/10/11

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA449392 | ENA
| PRJNA575001 | ENA
2021-02-12 | GSE150081 | GEO
| PRJNA312717 | ENA
2015-01-15 | E-GEOD-64970 | biostudies-arrayexpress
2015-01-15 | GSE64970 | GEO
2019-11-12 | PXD010414 | Pride
2018-08-02 | MSV000082745 | MassIVE
2020-03-06 | GSE146555 | GEO
2020-03-06 | GSE146554 | GEO