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Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway

ABSTRACT: Sea spray aerosols (SSAs) have profound effects on our climate and ecosystems. They also contain microbiota and biogenic molecules which could affect human health. Yet the exposure and effects of SSAs on human health remain poorly studied. Here, we exposed human lung cancer cells to extracts of a natural sea spray aerosol collected at the seashore in Belgium, a laboratory-generated SSA, the marine algal toxin homoyessotoxin and a chemical inhibitor of the mammalian target of rapamycin (mTOR) pathway. We observed significant increased expression of genes related to the mTOR pathway and Proprotein convertase subtilisin/kexin type 9 (PCSK9) after exposure to homoyessotoxin and the laboratory-generated SSA. In contrast, we observed a significant decrease in gene expression in the mTOR pathway and of PCSK9 after exposure to the natural SSA and the mTOR inhibitor, suggesting induction of apoptosis. Our results indicate that marine biogenics in SSAs interact with PCSK9 and the mTOR pathway and can be used in new potential pharmaceutical applications. Overall, our results provide a substantial molecular evidence base for potential beneficial health effects at environmentally relevant concentrations of natural SSAs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE113144 | GEO | 2018/12/27

REPOSITORIES: GEO

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Project description:The conservation and growth of natural capital accumulated in the seas and oceans is essential for the provision of sustainable ecosystem services and for the achievement of the EU’s Sustainable Development Goals (SDGs) set by the UN for 2030. Therefore, Marine Strategy Framework Directive (MSFD) offers a comprehensive and holistic approach for the protection of the European sea, acting as an environmental pillar of the EU’s broader maritime strategy. The blue economy conveys that a healthier sea is a more productive sea. Concretely, blue biotechnology, which uses, among others, shellfish, bacteria and algae for development in health care and energy production, needs a healthy ocean, biodiversity and biomass abundance to provide innovative substances that help in the production in innovative medicines for the maintenance of human health. Moreover, marine biomass has become a potent source of new and innovative biotechnological tools for new therapeutic strategies and compounds that will increases the utility of marine biomass valorization processes and the quest of new solutions to present diseases. Recently, proteomics approaches has highlighted its potential use to discover new activities with potential biotechnological applications from proteome data through “applied proteomics”. Finally, in the context of global climate change, it is also becoming more and more demanding to anticipate alterations and responses of bioindicator species and to create a database to prevent and predict the environmental and climatic changes before the damage being irreversible. In this project, The proteome analysis of the sea anemone, Anemonia sulcata and its symbiont will lead to the identification of gene expression biomarkers (GEBs), as emerging powerful diagnostic tools, for identifying and characterizing climate change drivers (temperature and irradiance) stress and improving monitoring techniques. In addition, By the application of novel algorithms to detect bioactive compounds based on the analysis of proteome marine-derived molecules will enable the identification of proteins with potential applications in agri-food and biomedicine fields.

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Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway

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