Transcriptomics

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Effect of EGFR activation on mouse chondrocytes


ABSTRACT: We examined the change of chondrocyte transcriptome after EGFR activation by TGF-α and inhibition by gefitinib. Data analysis showed that EGFR activation down-regulates cartilage ECM biosynthesis and promotes ECM degradation. Gefitinib can reverse the effects of EGFR on chondrocytes.

ORGANISM(S): Mus musculus

PROVIDER: GSE113271 | GEO | 2019/04/24

REPOSITORIES: GEO

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