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NHP gene expression after 4 Gy total body irradiation.

ABSTRACT: In the current study, we investigated the gene expression response of blood cells of non-human primates that were total body irradiated with a 4 Gy dose. We isolated total RNA from peripheral blood at 3 days before irradiation, and then from the same animals on days 3, 5 and 7 days after irradiation. Using Agilent Rhesus microarrays, we identified genes that were significantly differentially expressed across the 7-day time course of this study. We identified common biological functions affected that persisted across the 7-day study.

ORGANISM(S): Macaca mulatta

PROVIDER: GSE113478 | GEO | 2023/03/29

REPOSITORIES: GEO

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NHP gene expression after 4 Gy total body irradiation.

Project description:NHP gene expression after 4 Gy total body irradiation.

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Thorax irradiation of Non-Human Primates induces persistent gene expression changes in blood cells.

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Longitudinal multi-omic changes in the transcriptome and proteome of peripheral blood cells after a 4 Gy total body radiation dose to Rhesus macaques.

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