Transcriptomics

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Peroxide stress in Sigma54 mutant and Wt


ABSTRACT: Analyses of the Wild type and the sigma 54 mutant strain NZ7306 with and without peroxide treatment: A Lactobacillus plantarum strain with a deletion in the alternative sigma factor 54 (?54) encoding gene rpoN, displayed a 100 fold higher sensitivity to peroxide as compared to its parental strain. This feature could be due to ?54-dependent regulation of genes involved in peroxide stress response. However, transcriptome analyses of the wild type and the mutant strain during peroxide exposure did not support such a role for ?54. Subsequent experiments revealed that the impaired expression of the mannose PTS operon in the rpoN mutant caused the observed increased peroxide sensitivity. Keywords: genetic modification

ORGANISM(S): Lactiplantibacillus plantarum WCFS1 Lactiplantibacillus plantarum

PROVIDER: GSE11351 | GEO | 2008/05/08

SECONDARY ACCESSION(S): PRJNA106569

REPOSITORIES: GEO

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