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Distinct macrophage populations upon physiological changes in adipose tissue

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

OTHER RELATED OMICS DATASETS IN: PRJNA453187PRJNA453182PRJNA453154PRJNA451512

ORGANISM(S): Mus musculus

PROVIDER: GSE113595 | GEO | 2018/06/04

REPOSITORIES: GEO

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Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue.

Project description:Obesity is characterized by an accumulation of macrophages in adipose, some of which form distinct crown-like structures (CLS) around fat cells. While multiple discrete adipose tissue macrophage (ATM) subsets are thought to exist, their respective effects on adipose tissue, and the transcriptional mechanisms that underlie the functional differences between ATM subsets, are not well understood. We report that obese fat tissue of mice and humans contain multiple distinct populations of ATMs with unique tissue distributions, transcriptomes, chromatin landscapes, and functions. Mouse Ly6c ATMs reside outside of CLS and are adipogenic, while CD9 ATMs reside within CLS, are lipid-laden, and are proinflammatory. Adoptive transfer of Ly6c ATMs into lean mice activates gene programs typical of normal adipocyte physiology. By contrast, adoptive transfer of CD9 ATMs drives gene expression that is characteristic of obesity. Importantly, human adipose tissue contains similar ATM populations, including lipid-laden CD9 ATMs that increase with body mass. These results provide a higher resolution of the cellular and functional heterogeneity within ATMs and provide a framework within which to develop new immune-directed therapies for the treatment of obesity and related sequela.

| S-EPMC5984532 | biostudies-literature

Distinct macrophage populations upon physiological changes in adipose tissue [RNA-seq]

Project description:We report that obese fat tissue of mice contain multiple distinct populations of adipose tissue macrophage (ATM) with unique transcriptomes and chromatin landscapes. Mouse Ly6c ATMs express genes that are adipogenic, while CD9 ATMs express pro-inflammatory genes under the control of activating transcription factors. Adoptive transfer of Ly6c ATMs into lean mice activates gene programs typical of normal adipocyte physiology. By contrast, adoptive transfer of CD9 ATMs drives gene expression that is characteristic of obesity.

2018-06-04 | GSE113594 | GEO

Distinct macrophage populations upon physiological changes in adipose tissue [ATAC-seq]

2018-06-04 | GSE113583 | GEO

Distinct macrophage populations upon physiological changes in adipose tissue [scRNA-seq]

2018-06-04 | GSE113560 | GEO

Distinct macrophage populations upon physiological changes in adipose tissue

Project description:Distinct macrophage populations upon physiological changes in adipose tissue

| PRJNA453182 | ENA

Distinct macrophage populations upon physiological changes in adipose tissue [ATAC-seq]

Project description:Distinct macrophage populations upon physiological changes in adipose tissue [ATAC-seq]

| PRJNA453154 | ENA

Distinct macrophage populations upon physiological changes in adipose tissue [scRNA-seq]

Project description:Distinct macrophage populations upon physiological changes in adipose tissue [scRNA-seq]

| PRJNA451512 | ENA

Distinct macrophage populations upon physiological changes in adipose tissue [RNA-seq]

Project description:Distinct macrophage populations upon physiological changes in adipose tissue [RNA-seq]

| PRJNA453187 | ENA

Adipose Tissue Macrophage Accrual in Obesity

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-09-01 | GSE151093 | GEO

Weight loss independent changes in adipose tissue macrophage and T cell populations after sleeve gastrectomy in mice.

Project description:ObjectiveIn addition to adipocytes, adipose tissue contains large numbers of immune cells. A wide range of evidence links the activity of these cells to regulation of adipocyte and systemic metabolic function. Bariatric surgery improves several aspects of metabolic derangements and at least some of these effects occur in a weight-loss independent manner. We sought to investigate the impact of vertical sleeve gastrectomy (VSG) on adipose immune cell frequencies.MethodsWe analyzed the frequencies of immune cells within distinct adipose tissue depots in obese mice that had VSG or sham surgery with a portion of the latter group pair-fed such that their body mass was matched to the VSG animals.ResultsWe demonstrate that VSG induced a shift in the epididymal adipose tissue leukocyte profile including increased frequencies of CD11c- macrophages, increased frequencies of T cells (CD4+, CD8+, and CD4-/CD8- T cells all increased), but a significantly decreased frequency of adipose tissue dendritic cells (ATDC) that, despite the continued high fat feeding of the VSG group, dropped below control diet levels.ConclusionsThese results indicate that VSG induces substantial changes in the immune populations residing in the adipose depots independent of weight loss.

| S-EPMC5369283 | biostudies-literature

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