MICRO-RNA AS BIOMARKERS IN POMPE DISEASE
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ABSTRACT: We studied microRNAs as potential biomarkers for Pompe disease (PD). We analyzed microRNA expression by small RNA-seq in tissues from the PD mouse model at two different ages (3 and 9 months), and in plasma from 6 PD patients. In the PD mouse we found 211 microRNAs that were differentially expressed in gastrocnemii and 66 in heart, with a different pattern of expression at different ages. In a preliminary analysis in plasma from 6 PD patients 55 microRNAs were differentially expressed.
ORGANISM(S): Mus musculus Homo sapiens
PROVIDER: GSE113829 | GEO | 2018/11/21
REPOSITORIES: GEO
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