Genomics

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MICRO-RNA AS BIOMARKERS IN POMPE DISEASE


ABSTRACT: We studied microRNAs as potential biomarkers for Pompe disease (PD). We analyzed microRNA expression by small RNA-seq in tissues from the PD mouse model at two different ages (3 and 9 months), and in plasma from 6 PD patients. In the PD mouse we found 211 microRNAs that were differentially expressed in gastrocnemii and 66 in heart, with a different pattern of expression at different ages. In a preliminary analysis in plasma from 6 PD patients 55 microRNAs were differentially expressed.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE113829 | GEO | 2018/11/21

REPOSITORIES: GEO

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