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Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

ABSTRACT: To investigate the importance of STAT3 in the establishment of ES cells we have in a first step derived stable pluripotent embryonic stem cells from transgenic FVB mice expressing a conditional tamoxifen dependent STAT3-MER fusion protein. In a second step, STAT3-MER overexpressing cells were used to identify STAT3 pathway-related genes by expression profiling in order to identify new key-players involved in maintenance of pluripotency in ES cells. Keywords: Comparative expression analysis, STAT3 pathway related genes

ORGANISM(S): Mus musculus

PROVIDER: GSE11398 | GEO | 2008/06/01

SECONDARY ACCESSION(S): PRJNA106525

REPOSITORIES: GEO

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