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Evaluating Mice lacking Serum Carboxylesterase as a Behavioral Model for Nerve Agent Intoxication

ABSTRACT: Mice and other rodents typically used for nerve agent research have high concentrations of carboxylesterase in the blood that can act as natural scavengers for nerve agents. To develop an improved rodent system for the study of chemical warfare nerve agents, a serum carboxylesterase knock out mouse model was made (Es-1 knock out). This study utilized mRNA analysis to evaluate the effects of knocking out the serum carboxylesterase in a mouse model.

ORGANISM(S): Mus musculus

PROVIDER: GSE114024 | GEO | 2018/05/04

REPOSITORIES: GEO

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