Transcriptomics

Dataset Information

0

Gene expression analysis of cancer-associated fibroblasts (CAFs) from the murine breast cancer model MMTV-PyMT after perturbing the expression of Dickkopf-3 (DKK3)


ABSTRACT: Immortalized (hpv-E6) murine fibroblasts isolated from normal mammary glands and carcinoma stages (CAFs) from the MMTV-PyMT model (FVB/N background) were used in this analysis. CAFs were transfected with two independent RNAi targeting Dickkopf-3 (DKK3) or control RNAi and changes in whole-genome gene expression were evaluated by microarray. In addition, the effect of stable ectopic expression of DKK3 in normal fibroblasts (which normally do not express DKK3) was also evaluated. Analysis demonstrated the role of DKK3 in controlling specific transcriptional programs in CAFs.

ORGANISM(S): Mus musculus

PROVIDER: GSE114056 | GEO | 2018/05/05

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA464029 | ENA
2016-01-20 | GSE75925 | GEO
2013-03-31 | GSE39182 | GEO
2020-06-19 | GSE133035 | GEO
2024-07-30 | GSE273448 | GEO
2016-03-09 | E-GEOD-78982 | biostudies-arrayexpress
2023-11-06 | GSE240021 | GEO
2022-04-10 | PXD018343 | Pride
2015-08-22 | E-GEOD-58813 | biostudies-arrayexpress
2015-08-22 | GSE58813 | GEO