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CBX5 loss drives EGFR inhibitor resistance and results in therapeutically actionable vulnerabilities in lung cancer

ABSTRACT: The study evaluated the differential gene expression in CBX5 knockdown cells compared to control shRNA expressed HCC827 cells. Briefly, human lung cancer HCC827 cells stably expressing either CBX5 shRNAs or control shRNA were analysed for gene expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE114563 | GEO | 2023/01/05

REPOSITORIES: GEO

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Analysis of open chromatin structures in HCC827 CBX5 knockdown cells by ATAC seq analysis .

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CBX5 loss drives EGFR inhibitor resistance and results in therapeutically actionable vulnerabilities in lung cancer

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Maternal RNF114 plays critical roles in activation of the early zygotic genome through promoting ubiquitin-mediated degradation of Chromobox protein CBX5

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