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TRPS1 is a lineage-specific transcriptional dependency in breast cancer

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE114600 | GEO | 2018/10/03

REPOSITORIES: GEO

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TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer.

Project description:Perturbed epigenomic programs play key roles in tumorigenesis, and chromatin modulators are candidate therapeutic targets in various human cancer types. To define singular and shared dependencies on DNA and histone modifiers and transcription factors in poorly differentiated adult and pediatric cancers, we conducted a targeted shRNA screen across 59 cell lines of 6 cancer types. Here, we describe the TRPS1 transcription factor as a strong breast cancer-specific hit, owing largely to lineage-restricted expression. Knockdown of TRPS1 resulted in perturbed mitosis, apoptosis, and reduced tumor growth. Integrated analysis of TRPS1 transcriptional targets, chromatin binding, and protein interactions revealed that TRPS1 is associated with the NuRD repressor complex. These findings uncover a transcriptional network that is essential for breast cancer cell survival and propagation.

| S-EPMC6366939 | biostudies-literature

TRPS1 is a lineage-specific transcriptional dependency in breast cancer [Seq]

Project description:We performed an unbiased cell viability-based pooled shRNA screen on 59 cell lines to identify novel epigenetic and transcriptional dependencies of multiple cancer types, including leukemia, neuroblastoma, breast, colorectal, prostate, and rhabdoid tumors. Here, we identified Tricho-Rhino-Phalangeal Syndrome Type I protein (TRPS1) as one of the most significant hits specific for breast cancer cell lines. Downregulation of TRPS1 resulted in cell cycle arrest and apoptosis increase in vitro and impaired tumorigenic capacity in vivo. We characterized TRPS1 genomic targets and protein interactome. We identified GATAD2B as an important partner of TRPS1, uncovering novel epigenetic network crucial for breast cancer cell survival.

2018-10-03 | GSE114597 | GEO

TRPS1 is a lineage-specific transcriptional dependency in breast cancer [methylation array]

2018-10-03 | GSE114598 | GEO

TRPS1 is a lineage-specific transcriptional dependency in breast cancer

Project description:TRPS1 is a lineage-specific transcriptional dependency in breast cancer

| PRJNA471878 | ENA

TRPS1 is a lineage-specific transcriptional dependency in breast cancer [Seq]

Project description:TRPS1 is a lineage-specific transcriptional dependency in breast cancer [Seq]

| PRJNA471883 | ENA

TRPS1 is a lineage-specific transcriptional dependency in breast cancer [methylation array]

Project description:TRPS1 is a lineage-specific transcriptional dependency in breast cancer [methylation array]

| PRJNA471882 | ENA

TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-08-07 | GSE107023 | GEO

Global transcriptional role of CtBP in breast cancer cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-03-20 | E-GEOD-36598 | biostudies-arrayexpress

CDK7-dependent Transcriptional Addition in Basal-like Breast Cancer

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-05-21 | E-GEOD-69107 | biostudies-arrayexpress

TRPS1 acts as a context-dependent regulator of mammary epithelial cell growth/differentiation and breast cancer development

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-12-05 | GSE133075 | GEO

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