Transcriptomics

Dataset Information

0

Total RNA profiles in response to four tyrosine kinase inhibitors in human induced pluripotent stem cell-derived cardiomyocytes


ABSTRACT: To define molecular markers of tyrosine kinase inhibitor-induced cardiotoxicity, we measured transcriptome changes in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) treated with one of four tyrosine kinase inhibitors (Erlotinib, Lapatinib, Sorafenib, or Sunitinib) displaying a range of mild to severe cardiotoxicity or a vehicle-only control (DMSO). Gene expression changes were assessed at the cell population level using total RNA-seq, which measured levels of both mRNAs and non-coding RNAs. hiPSC-CMs used in this study were the Cor.4U cells purchased from Ncardia.

ORGANISM(S): Homo sapiens

PROVIDER: GSE114686 | GEO | 2019/03/23

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2019-05-16 | PXD012043 | Pride
2012-05-29 | E-GEOD-38310 | biostudies-arrayexpress
2016-11-02 | GSE89410 | GEO
2018-02-13 | GSE98973 | GEO
2017-05-16 | ST000893 | MetabolomicsWorkbench
2017-05-16 | ST000894 | MetabolomicsWorkbench
2017-05-16 | ST000896 | MetabolomicsWorkbench
2017-05-16 | ST000895 | MetabolomicsWorkbench
| PRJNA352077 | ENA
2023-09-01 | GSE241223 | GEO