Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Prediabetes Induced by a Single Autoimmune B cell Clone [RNA-seq]

ABSTRACT: SCNT-derived B cell model displays spontaneous germinal center reaction, infiltration of pancreas (in RAG1-/- background) and impaired glucose tolerance.

ORGANISM(S): Mus musculus

PROVIDER: GSE114829 | GEO | 2020/05/26

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Prediabetes Induced by a Single Autoimmune B cell Clone [ATAC-seq]

Project description:SCNT-derived B cell model displays spontaneous germinal center reaction, infiltration of pancreas (in RAG1-/- background) and impaired glucose tolerance.

2020-05-26 | GSE114830 | GEO

Prediabetes Induced by a Single Autoimmune B Cell Clone.

Project description:While B cells play a significant role in the onset of type-1 diabetes (T1D), little is know about their role in those early stages. Thus, to gain new insights into the role of B cells in T1D, we converted a physiological early pancreas-infiltrating B cell into a novel BCR mouse model using Somatic Cell Nuclear Transfer (SCNT). Strikingly, SCNT-derived B1411 model displayed neither developmental block nor anergy. Instead, B1411 underwent spontaneous germinal center reactions. Without T cell help, B1411-Rag1-/- was capable of forming peri-/intra-pancreatic lymph nodes, and undergoing class-switching. RNA-Seq analysis identified 93 differentially expressed genes in B1411 compared to WT B cells, including Irf7, Usp18, and Mda5 that had been linked to a potential viral etiology of T1D. We also found various members of the oligoadenylate synthase (OAS) family to be enriched in B1411, such as Oas1, which had recently also been linked to T1D. Strikingly, when challenged with glucose B1411-Rag1-/- mice displayed impaired glucose tolerance.

| S-EPMC7314986 | biostudies-literature

Prediabetes Induced by a Single Autoimmune B cell Clone

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-05-26 | GSE114831 | GEO

Prediabetes Induced by a Single Autoimmune B cell Clone

Project description:Prediabetes Induced by a Single Autoimmune B cell Clone

| PRJNA472780 | ENA

NGS-mRNA in lung tissues in RAG1-/- and in RAG1-/- Sgo1-/+ mice

Project description:We compared lung mRNA expression profiles between RAG1-/- control and RAG1-/- Sgo1-/+ chromosome instability model mice. RAG1-/-Sgo1-/+ mice developed significantly more spontaneous lung tumors.

2017-02-09 | GSE84383 | GEO

The equine granulocyte proteome: expression changes in autoimmune disease and after stimulation

Project description:We investigated the granulocyte proteome from healthy horses, horses with a spontaneous autoimmune disease (equine recurrent uveitis) and the reaction of granulocytes to different stimuli (IL8, PMA, LPS) on protein level. A total of 2032 proteins describing the whole granulocyte proteome were identified, including 245 proteins (12% of proteome) newly associated to in vivo expression in primary granulocytes (hypothetical proteins). Our studies provide novel information on the granulocyte proteome and contribute to a better understanding of molecular mechanisms involved in activation and recruitment of neutrophils and the role of these cells in modulating and regulating autoimmune diseases. The data presented here is highly relevant for veterinary medicine and has translational quality for spontaneous autoimmune uveitis in man.

2020-01-15 | PXD013648 | Pride

Prediabetes Induced by a Single Autoimmune B cell Clone [RNA-seq]

Project description:Prediabetes Induced by a Single Autoimmune B cell Clone [RNA-seq]

| PRJNA472781 | ENA

Prediabetes Induced by a Single Autoimmune B cell Clone [ATAC-seq]

Project description:Prediabetes Induced by a Single Autoimmune B cell Clone [ATAC-seq]

| PRJNA472782 | ENA

Genome-wide analysis of gene expression in mouse pancreas tumors

2015-11-20 | GSE66981 | GEO

Genome-wide analysis of gene expression in mouse pancreas tumors

Project description:Genetically engineered mice developed spontaneous pancreas cancer (Pdx-Cre;LSL-KRASG12D;P53Mut). Mice were also engineered to develop similar spontaneous pancreas cancer without Twist or Snail (conditional gene knockout). The pancreas tumors were harvested and analysed for gene expression profiles comparisons. Total RNA was isolated from the pancreas tumors of 2 mice with wild-type Twist and Snail, from 2 mice without Twist expression in the pancreas, and from 2 mice without Snail expression in the pancreas.

2015-11-20 | E-GEOD-66981 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data