Transcriptomics

Dataset Information

0

Long-term persistent infection with equine arteritis virus is associated with the upregulation of specific CD8+ T lymphocyte transcription factors, inhibitory receptors, and the CXCL16/CXCR6 axis in the ampullae of the stallion reproductive tract


ABSTRACT: We performed whole transcriptome analysis of the ampullae, the primary site of EAV persistence, derived from long-term carrier stallions to understand the molecular signature of persistent infection. We demonstrated that long-term persistence is characterized by a local CD8+ T lymphocyte response predominantly driven by the transcription factors EOMES and NFATC2.We showed that EAV persistence is associated with an enhanced expression of CXCL16/CXCR6 in infiltrating lymphocytes. Furthermore, we established a link between the CXCL16 genotype and the gene expression profile at the site of persistence following EAV infection. Co-expression network analysis identified CXCL16 as a “hub” gene, likely driving a specific transcriptional network.

ORGANISM(S): Equus caballus

PROVIDER: GSE114982 | GEO | 2019/07/16

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-07-29 | GSE180647 | GEO
| PRJNA473438 | ENA
2021-06-30 | GSE179111 | GEO
2022-07-20 | GSE208584 | GEO
2013-04-09 | E-GEOD-45881 | biostudies-arrayexpress
2015-06-30 | E-GEOD-60484 | biostudies-arrayexpress
| S-EPMC6692045 | biostudies-literature
| PRJNA749023 | ENA
| S-EPMC8306453 | biostudies-literature
2015-06-30 | GSE60484 | GEO