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IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (ChIP-Seq)

ABSTRACT: Using integrative bioinformatics analyses, we identified new IRF5 primary target genes in mouse DCs in response to virus infection. This study provides novel insights into the distinct and unique innate immune and immune gene regulatory program directed by IRF5.

ORGANISM(S): Mus musculus

PROVIDER: GSE114991 | GEO | 2018/12/14

REPOSITORIES: GEO

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IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (RNA-Seq)

Project description:Using integrative bioinformatics analyses, we identified new IRF5 primary target genes in mouse DCs in response to virus infection. This study provides novel insights into the distinct and unique innate immune and immune gene regulatory program directed by IRF5.

2018-12-14 | GSE114992 | GEO

IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (BMM_RNA-Seq)

2018-12-14 | GSE118452 | GEO

IRF5 regulates unique subset of genes in dendritic cells during West Nile virus infection.

Project description:Pathogen recognition receptor (PRR) signaling is critical for triggering innate immune activation and the expression of immune response genes, including genes that impart restriction against virus replication. RIG-I-like receptors and TLRs are PRRs that signal immune activation and drive the expression of antiviral genes and the production of type I IFN leading to induction of IFN-stimulated genes, in part through the interferon regulatory factor (IRF) family of transcription factors. Previous studies with West Nile virus (WNV) showed that IRF3 and IRF7 regulate IFN expression in fibroblasts and neurons, whereas macrophages and dendritic cells (DCs) retained the ability to induce IFN-? in the absence of IRF3 and IRF7 in a manner implicating IRF5 in PRR signaling actions. Here we assessed the contribution of IRF5 to immune gene induction in response to WNV infection in DCs. We examined IRF5-dependent gene expression and found that loss of IRF5 in mice resulted in modest and subtle changes in the expression of WNV-regulated genes. Anti-IRF5 chromatin immunoprecipitation with next-generation sequencing of genomic DNA coupled with mRNA analysis revealed unique IRF5 binding motifs within the mouse genome that are distinct from the canonical IRF binding motif and that link with IRF5-target gene expression. Using integrative bioinformatics analyses, we identified new IRF5 primary target genes in DCs in response to virus infection. This study provides novel insights into the distinct and unique innate immune and immune gene regulatory program directed by IRF5.

| S-EPMC6355374 | biostudies-literature

IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-12-14 | GSE114993 | GEO

IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection

Project description:IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection

| PRJNA473488 | ENA

IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (RNA-Seq)

Project description:IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (RNA-Seq)

| PRJNA473490 | ENA

IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (ChIP-Seq)

Project description:IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (ChIP-Seq)

| PRJNA473491 | ENA

IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (BMM_RNA-Seq)

Project description:IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (BMM_RNA-Seq)

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IRF5 and IRF3 regulate distinct immune programs in plasmacytoid dendritic cells

Project description:Transcriptomic analyses of pDCs show that the partitioning of TLR/IRF5 and RLR/IRF3 pathways confers differential gene expression and immune cytokine production in pDCs, linking IRF5 with immune regulatory and proinflammatory gene expression.

2017-12-27 | GSE108526 | GEO

Specificity of enhancer selection by IRF3, IRF5 and IRF9 in dendritic cells

Project description:To discover the key determinants of IRF-specific enhancer selection, we identified and characterized IRF binding regions. Using chromatin immunoprecipitation coupled with deep sequencing (ChIP-seq), we mapped the binding regions of IRF3, IRF5, and IRF9 in murine dendritic cells (DCs) stimulated with TLR3 and TLR9 agonists, as well as IFNβ, respectively. We comprehensively analysed the IRF cistromes to identify characteristic features, including DNA motifs for IRFs and other transcription factors, and chromatin status.

2019-07-31 | GSE125340 | GEO

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