Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Simultaneous control of non-coding RNA on the G2/M phase of the cell cycle in hepatocellular carcinoma

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): synthetic construct Homo sapiens

PROVIDER: GSE115019 | GEO | 2018/05/30

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Coordinative control of G2/M phase of the cell cycle by non-coding RNAs in hepatocellular carcinoma.

Project description:ObjectiveTo investigate the interaction of non-coding RNAs (ncRNAs) in hepatocellular carcinoma.MethodsWe compared the ncRNAs and mRNAs expression profiles of hepatocellular carcinoma and adjacent tissue by microarray and RT-PCR. The relationship between different ncRNAs and mRNA was analyzed using bioinformatics tools. A regulatory model of ncRNAs in hepatocellular carcinoma cells was developed.ResultsA total of 1,704 differentially expressed lncRNAs, 57 miRNAs, and 2,093 mRNAs were identified by microarray analyses. There is a co-expression relationship between two ncRNAs (miRNA-125b-2-3p and lncRNA P26302). Bioinformatics analysis demonstrated cyclin-dependent kinases 1 and CyclinA2 as potential targets of miR-125b-2-3p and Polo-like kinase 1 as potential target of lncRNAP26302. All three gene are important components in the G2/M phase of cell cycle. Subsequently real-time polymerase chain reaction (PCR) studies confirmed these microarray results.ConclusionMiR-125b-2-3p and lncRNAP26302 may affect the G2/M phase of the cell cycle through the regulation of their respective target genes. This study shows a role of ncRNAs in pathogenesis of hepatocellular carcinoma at molecular level, providing a basis for the future investigation aiming at early diagnosis and novel treatment of hepatocellular carcinoma.

| S-EPMC6197396 | biostudies-literature

Simultaneous control of non-coding RNA on the G2/M phase of the cell cycle in hepatocellular carcinoma [miRNA]

Project description:The differential ncRNA and mRNA expression profile was compared between hepatocellular carcinoma and paracancerous normal tissues by microarray We use microarray to detail the gene expression of hepatocellular carcinoma and paracancerous normal tissues and Identify differentially expressed genes

2018-05-30 | GSE115016 | GEO

Simultaneous control of non-coding RNA on the G2/M phase of the cell cycle in hepatocellular carcinoma [lncRNA and mRNA]

2018-05-30 | GSE115018 | GEO

Simultaneous control of non-coding RNA on the G2/M phase of the cell cycle in hepatocellular carcinoma

Project description:Simultaneous control of non-coding RNA on the G2/M phase of the cell cycle in hepatocellular carcinoma

| PRJNA473522 | ENA

Simultaneous control of non-coding RNA on the G2/M phase of the cell cycle in hepatocellular carcinoma [miRNA]

Project description:Simultaneous control of non-coding RNA on the G2/M phase of the cell cycle in hepatocellular carcinoma [miRNA]

| PRJNA473523 | ENA

Simultaneous control of non-coding RNA on the G2/M phase of the cell cycle in hepatocellular carcinoma [lncRNA and mRNA]

Project description:Simultaneous control of non-coding RNA on the G2/M phase of the cell cycle in hepatocellular carcinoma [lncRNA and mRNA]

| PRJNA473525 | ENA

FEN1 Promotes Hepatocellular Carcinoma Progression by Activating Cell Cycle Transition from G2 To M Phase

Project description: Not available

| S-EPMC10788719 | biostudies-literature

Long non-coding RNAs and hepatocellular carcinoma.

Project description:Recent advances in next-generation sequencing technology in transcriptome analysis have helped identify numerous non-coding RNAs. The long non-coding RNA (lncRNA) is commonly defined as an RNA molecule with a length of 200 bp-100 kbp that lacks protein-coding potential. LncRNAs play a critical role in the regulation of gene expression, including chromatin modification, transcription and post-transcriptional processing. It has been confirmed that dysregulation of lncRNAs is associated with a number of human diseases, particularly tumors. In this study, we focused on the most extensively investigated lncRNAs in hepatocellular carcinoma (HCC). The biological functions and molecular mechanisms of the majority of lncRNAs have yet to be investigated. The improved knowledge on lncRNAs in HCC may help identify lncRNAs that may be used as novel prognostic markers and therapeutic targets.

| S-EPMC4251171 | biostudies-literature

Non coding RNA analysis in fibrolamellar hepatocellular carcinoma.

Project description:Fibrolamellar hepatocellular carcinoma (FLC) is a rare primary liver cancer found in adolescents and young adults without underlying liver disease. A deletion of ~400 kD has been found in one copy of chromosome 19 in the tumor tissue of all patients tested. This produces a fusion of the genes DNAJB1 and PRKACA which, in turn, produces a chimeric transcript and protein. Transcriptomic analysis of the tumor has shown upregulation of various oncologically relevant pathways, including EGF/ErbB, Aurora Kinase A, pak21 and wnt. To explore other factors that may contribute to oncogenesis, we examined the microRNA (miRNA) and long non-coding RNA (lncRNA) expression in FLC. The non-coding RNA expression profile in tumor tissue samples is distinctly different from the adjacent normal liver and from other liver tumors. Furthermore, miRZip knock down or over expression of certain miRNAs led to changes in the levels of coding genes that recapitulated changes observed in FLC, suggesting mechanistically that the changes in the cellular levels of miRNA are not merely correlative. Thus, in addition to serving as diagnostic tools for FLC, non-coding RNAs may serve as therapeutic targets.

| S-EPMC5828204 | biostudies-literature

p53-inducible long non-coding RNAs encode functional peptides in hepatocellular carcinoma cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-07-18 | GSE125758 | GEO