Distinct immune responses to type I and III interferons are regulated by interferon regulatory factor 1
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ABSTRACT: Type I and III interferons (IFNs) are critical antiviral molecules thought to activate similar signaling cascades resulting in the induction of shared downstream IFN-stimulated genes. This study reveals an unappreciated fundamental difference in the signal transduction downstream of type I and type III IFNs that has broad implications for their functionalities during infection and inflammation.
ORGANISM(S): Homo sapiens
PROVIDER: GSE115198 | GEO | 2019/09/30
REPOSITORIES: GEO
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