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Discovery of YAP target genes with TNFa or IL-1b induction

ABSTRACT: Proper inflammatory responses are vital to restore tissue homeostasis against offending factors. However, it is largely under explored whether inflammatory responses are modulated by the Hippo effectors YAP/TAZ. To identify the transcription targets related to inflammatory reponses for YAP, we utilized human bronchioalveolar carcinoma cells H358 expressing YAP(5SA) or GFP (as a control) and treated with vehicle, TNFa or IL-1b, respectively. Our work disclosed the complex features of YAP/TAZ’s role in inflammatory responses.

ORGANISM(S): Homo sapiens

PROVIDER: GSE115207 | GEO | 2018/06/02

REPOSITORIES: GEO

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