Transcriptomics

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Transcriptional profile of Th17 cells: The role of glycolysis


ABSTRACT: The aim of this study is to investigate a role of glycolysis in transcriptional programing of Th17 cells during differentiation. Naïve CD4 T cells were differentiated towards Th17 cells with or without a mild inhibition of glycolysis, and transcriptome signature was analyzed. We found about 200 transcripts were differentially regulated. Further pathway analysis suggested that glycolysis controls genes associated with IL-2/STAT5 signaling during Th17 differentiation. Inhibition of glycolysis resulted in enrichment of genes associated with translational processes and Th17 signature genes.

ORGANISM(S): Mus musculus

PROVIDER: GSE115339 | GEO | 2020/06/01

REPOSITORIES: GEO

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