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RNA-seq of HIV bnAb and control individuals PBMC

ABSTRACT: We sought to determine differences in transcript expression between a cohort of HIV-infected individuals that either developed broadly neutralizing antibodies (bnAb) or did not develop them (control). With the ultimate goal to identify transcripts that are associated with the development of bnAbs that would identify novel pathways that could be targeted in future vaccine strategies to increase the frequency of individuals that develop bnAbs against HIV. Using this approach we identified that Rab11 recycling endosomes, particularly in dysfunctional natural killer cells are associated with the development of HIV-1 bnAbs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE115449 | GEO | 2018/11/01

REPOSITORIES: GEO

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Human Immunoglobulin Repertoire-Guided Immunogen Design Targeting HIV V2-Apex Broadly Neutralizing Antibody Precursors

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RNA-seq of HIV bnAb and control individuals PBMC

Project description:RNA-seq of HIV bnAb and control individuals PBMC

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