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Exosome-transmitted RVT1 from reactive astrocytes promotes recurrence glioblastoma proliferation

ABSTRACT: Glioblastoma (GBM) remains among the most lethal brain tumors despite improvements in treatment. Surgical resection is a universal component of glioma therapy. However, the mechanism underlying postoperative recurrence remains a challenge due to limited information regarding the changes that occur in the postoperative microenvironment. Here, we show that a subtype of proinflammatory reactive astrocytes designated is induced by inflammatory cytokines or injury. We show that reactive astrocytes can secrete the long noncoding RNA (lncRNA) LOC646762 to promotes recurrence glioblastoma proliferation in an exosome-dependent manner.We firstly named this reactive astrocyte associated lnRNA as “lnc-RVT1”.

ORGANISM(S): Homo sapiens

PROVIDER: GSE115459 | GEO | 2018/06/08

REPOSITORIES: GEO

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Exosome-transmitted RVT1 from reactive astrocytes promotes recurrence glioblastoma proliferation

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