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Inhibition of a G9a/DNMT network triggers an immune-mediated bladder cancer regression

ABSTRACT: Using a novel immunocompetent quadruple (PtenF/F; Trp53F/F; Rb1F/F;Rbl1-/-) knockout transgenic mouse model of highly aggressive metastatic muscle-invasive BC, we demonstrate that treatment with CM272 and CDDP results in a significant tumor and metastasis regression with a very significant prolonged survival

ORGANISM(S): Mus musculus

PROVIDER: GSE115485 | GEO | 2019/02/01

REPOSITORIES: GEO

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