Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Allelic specificity of IGH-DUX4 translocation in acute lymphoblastic leukemia (ALL)

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE115494 | GEO | 2019/05/08

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Allelic specificity of IGH-DUX4 translocation in acute lymphoblastic leukemia (ALL) [H3K27Ac HiChIP]

Project description:In Nalm6, mono-allelic interaction between IGH enhancer and IGH promoter was found from H3K27ac HiChIP data.

2019-05-08 | GSE115492 | GEO

Allelic specificity of IGH-DUX4 translocation in acute lymphoblastic leukemia (ALL) [Hi-C]

Project description:In Nalm6, mono-allelic interaction between IGH enhancer and IGH promoter was found from Hi-C data.

2019-05-08 | GSE115491 | GEO

Allelic specificity of IGH-DUX4 translocation in acute lymphoblastic leukemia (ALL) [ATAC-seq]

Project description:In Nalm6, allelic imbalance was found at IGH-DUX4 translocation locus from ATAC-seq data.

2019-05-08 | GSE115482 | GEO

Allelic specificity of IGH-DUX4 translocation in acute lymphoblastic leukemia (ALL) [Capture-C]

Project description:In Nalm6, mono-allelic interaction between IGH enhancer and IGH promoter was found from Capture-C data.

2019-05-08 | GSE115493 | GEO

Allelic specificity of IGH-DUX4 translocation in acute lymphoblastic leukemia (ALL) [H3K27ac ChIP-seq]

Project description:In Nalm6, allelic imbalance was found at IGH-DUX4 translocation locus from H3K27ac ChIP-seq data.

2019-05-08 | GSE116137 | GEO

Allelic specificity of IGH-DUX4 translocation in acute lymphoblastic leukemia (ALL)

Project description:Allelic specificity of IGH-DUX4 translocation in acute lymphoblastic leukemia (ALL)

| PRJNA475155 | ENA

Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia.

Project description:IGH@ proto-oncogene translocation is a common oncogenic event in lymphoid lineage cancers such as B-ALL, lymphoma and multiple myeloma. Here, to investigate the interplay between IGH@ proto-oncogene translocation and IGH allelic exclusion, we perform long-read whole-genome and transcriptome sequencing along with epigenetic and 3D genome profiling of Nalm6, an IGH-DUX4 positive B-ALL cell line. We detect significant allelic imbalance on the wild-type over the IGH-DUX4 haplotype in expression and epigenetic data, showing IGH-DUX4 translocation occurs on the silenced IGH allele. In vitro, this reduces the oncogenic stress of DUX4 high-level expression. Moreover, patient samples of IGH-DUX4 B-ALL have similar expression profile and IGH breakpoints as Nalm6, suggesting a common mechanism to allow optimal dosage of non-toxic DUX4 expression.

| S-EPMC6594946 | biostudies-literature

Allelic specificity of IGH-DUX4 translocation in acute lymphoblastic leukemia (ALL) [Hi-C]

Project description:Allelic specificity of IGH-DUX4 translocation in acute lymphoblastic leukemia (ALL) [Hi-C]

| PRJNA477383 | ENA

Allelic specificity of IGH-DUX4 translocation in acute lymphoblastic leukemia (ALL) [H3K27Ac HiChIP]

Project description:Allelic specificity of IGH-DUX4 translocation in acute lymphoblastic leukemia (ALL) [H3K27Ac HiChIP]

| PRJNA475158 | ENA

Allelic specificity of IGH-DUX4 translocation in acute lymphoblastic leukemia (ALL) [Capture-C]

Project description:Allelic specificity of IGH-DUX4 translocation in acute lymphoblastic leukemia (ALL) [Capture-C]

| PRJNA475159 | ENA