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Gene expression profile of the RAG2/pfp gene depletion on Spleen of mouse

ABSTRACT: It contains a disruption of the recombination activating gene 2 (RAG2)/pfp and fail to generate mature T or B or NK lymphocytes. (https://www.taconic.com)

ORGANISM(S): Mus musculus

PROVIDER: GSE115519 | GEO | 2019/01/01

REPOSITORIES: GEO

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Gene expression profile of the RAG2/pfp gene depletion on Thymus of mouse

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Gene expression profile of the RAG2/pfp gene depletion on Spleen of mouse

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Gene expression profile of the RAG2/pfp gene depletion on LN of mouse

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Gene expression profile of the RAG2 gene depletion on pig spleen

Project description:Pigs with severe combined immunodeficiency (SCID) may provide useful models for regenerative medicine, xenotransplantation, and tumor development and will aid in developing therapies for human SCID patients. Using a reporter-guided transcription activator-like effector nuclease (TALEN) system, we generated targeted modifications of recombination activating gene (RAG) 2 in somatic cells at high efficiency, including some that affected both alleles. Somatic-cell nuclear transfer performed with the mutated cells produced pigs with RAG2 mutations without integrated exogenous DNA. Biallelically modified pigs either lacked a thymus or had one that was underdeveloped. Their splenic white pulp lacked B and T cells. Under a conventional housing environment, the biallelic RAG2 mutants manifested a failure to thrive phenotype, with signs of inflammation and apoptosis in the spleen compared with age-matched wild-type animals by the time they were 4 wk of age. Pigs raised in a clean environment were healthier and, following injection of human induced pluripotent stem cells (iPSCs), quickly developed mature teratomas representing all three germ layers. The pigs also tolerated grafts of allogeneic porcine trophoblast stem cells. These SCID pigs should have a variety of uses in transplantation biology.

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