Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing [smallRNA-Seq]

ABSTRACT: We found PEAT complexes mediate histone deacetylation and heterochromatin condensation and thereby facilitate heterochromatin silencing.

ORGANISM(S): Arabidopsis thaliana

PROVIDER: GSE116067 | GEO | 2018/06/21

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing [RNA-Seq]

Project description:We found PEAT complexes mediate histone deacetylation and heterochromatin condensation and thereby facilitate heterochromatin silencing.

2018-06-21 | GSE116066 | GEO

The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing [ChIP-Seq]

Project description:We found PEAT complexes mediate histone deacetylation and heterochromatin condensation and thereby facilitate heterochromatin silencing.

2018-06-21 | GSE116065 | GEO

The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing [BS-Seq]

Project description:We found PEAT complexes mediate histone deacetylation and heterochromatin condensation and thereby facilitate heterochromatin silencing.

2018-06-21 | GSE116064 | GEO

The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing [smallRNA-Seq]

Project description:The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing [smallRNA-Seq]

| PRJNA476943 | ENA

The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing

Project description:The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing

| PRJNA476936 | ENA

The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing [BS-Seq]

Project description:The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing [BS-Seq]

| PRJNA476940 | ENA

The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing [ChIP-Seq]

Project description:The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing [ChIP-Seq]

| PRJNA476941 | ENA

The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing [RNA-Seq]

Project description:The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing [RNA-Seq]

| PRJNA476942 | ENA

The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing.

Project description:In eukaryotes, heterochromatin regions are typically subjected to transcriptional silencing. DNA methylation has an important role in such silencing and has been studied extensively. However, little is known about how methylated heterochromatin regions are subjected to silencing. We conducted a genetic screen and identified an epcr (enhancer of polycomb-related) mutant that releases heterochromatin silencing in Arabidopsis thaliana We demonstrated that EPCR1 functions redundantly with its paralog EPCR2 and interacts with PWWP domain-containing proteins (PWWPs), AT-rich interaction domain-containing proteins (ARIDs), and telomere repeat binding proteins (TRBs), thus forming multiple functionally redundant protein complexes named PEAT (PWWPs-EPCRs-ARIDs-TRBs). The PEAT complexes mediate histone deacetylation and heterochromatin condensation and thereby facilitate heterochromatin silencing. In heterochromatin regions, the production of small interfering RNAs (siRNAs) and DNA methylation is repressed by the PEAT complexes. The study reveals how histone deacetylation, heterochromatin condensation, siRNA production, and DNA methylation interplay with each other and thereby maintain heterochromatin silencing.

| S-EPMC6166130 | biostudies-literature

The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing

Project description:In eukaryotes, heterochromatin regions are typically subjected to transcriptional silencing. DNA methylation has an important role in such silencing, and has been studied extensively. However, little is known about how methylated heterochromatin regions are subjected to silencing. We conducted a genetic screen and identified an epcr (enhancer of polycomb-related) mutant that releases heterchromatin silencing in Arabidopsis thaliana. We demonstrated that EPCR1 functions redundantly with its paralog EPCR2 and interacts with PWWP domain-containing proteins (PWWPs), AT-rich interaction domain-containing proteins (ARIDs), and telomere repeat binding proteins (TRBs), thus forming multiple functionally redundant protein complexes named PEAT (PWWPs-EPCRs-ARIDs-TRBs). The PEAT complexes mediate histone deacetylation and heterochromatin condensation and thereby facilitate heterochromatin silencing. In heterochromatin regions, the production of small interfering RNAs (siRNAs) and DNA methylation are repressed by the PEAT complexes. The study reveals how histone deacetylation, heterochromatin condensation, siRNA production, and DNA methylation interplay with each other and thereby maintain heterochromatin silencing.

| S-SCDT-EMBOJ-2017-98770 | biostudies-other

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data