Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

KCa3.1 depletion effect on hepatocellular carcinoma cell line Huh7

ABSTRACT: Analysis of Huh7 hepatocellular carcinoma (HCC) cells depleted for potassium channel KCa3.1, the intermediate conductance calcium-activated potassium channel. Result provide insight into the role of KCa3.1 in the carcinogenesis of HCC. We used microarrays to detail the gene expression differences between KCa3.1 knockdown and negative control in Huh7 HCC cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE116183 | GEO | 2018/06/23

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Gene expression profiles in CD44- and CD44+ hepatocellular carcinoma HuH7 cells

Project description:To investigate the significance of CD44+ hepatocellular carcinoma (HCC) HuH7 cells, gene expression profiles of CD44-positive HuH7, CD44-negative HuH7, and human nomal hepatocyes were analyzed. Results provide the insight into the significance of CD44-positive HCC cells as the liver CSCs.

2016-09-01 | GSE84223 | GEO

microRNA expression profiles in CD44- and CD44+ hepatocellular carcinoma HuH7 cells

Project description:To investigate the significance of CD44+ hepatocellular carcinoma (HCC) HuH7 cells, microRNA (miRNA) expression profiles of CD44-positive HuH7, CD44-negative HuH7, and human nomal hepatocyes were analyzed. Results provide the insight into the significance of CD44-positive HCC cells as the liver CSCs.

2016-09-01 | GSE84224 | GEO

Changes in total RNA in BK deficient mice after 4h sleep deprivation [pools]

Project description:Animals deficient for the alpha subunit of the large conductance calcium dependent potassium channel (BK) were sleep deprived for 4 hours and compared to wildtype littermates as well as animals (wildtype littermate and BK deficient) left undisturbed for the same time.

2019-07-31 | GSE132075 | GEO

Changes in total RNA in BK deficient mice after 4h sleep deprivation [individuals]

2019-07-31 | GSE132074 | GEO

Effect of depletion of RAD51 on gene expression in Huh7 cells

Project description:To investigate the role of RAD51 in HCC, we established Huh7 cell lines in which RAD51 has been knocked down(KD) by sgRNA,we performed RNA-seq for RAD51-KD Huh7 cells and parental Huh7 cells(control group,sgcon).

2023-05-17 | GSE216728 | GEO

Effect of depletion of METTL16 on gene expression of Huh7 liver cancer cells [RNA-seq]

Project description:To investigate the mechanism of METTL16 in the regulation of tranlation and HCC development, we established Huh7 cell lines following METTL16 knockout (KO) by CRISPER-Cas9 system. We then performed gene expression profiling analysis using data obtained from RNA-seq of Huh7 cells.

2024-01-30 | GSE224008 | GEO

Transcriptomics of an in vitro model of sorafenib resistance in Huh7 hepatocellular carcinoma cell line

Project description:Hepatocellular carcinoma (HCC) is often diagnosed in patients with advanced disease who are ineligible for curative surgical therapies. Sorafenib, a multi-kinase inhibitor, is currently the only approved drug used in treating such patients. However, patients rapidly become unresponsive due to inherent and acquired drug resistance. To better understand the molecular mechanisms underlying sorafenib resistance in HCC at a global level in an unbiased manner, we conducted gene expression analysis using in vitro models of HCC sorafenib resistance using the Huh7 cell line, including a resistant pool of cells and a specific clone derived from the resistant pool.

2019-09-01 | GSE94550 | GEO

Hepatocellular carcinoma Huh7: siHINT1 vs. siControl

Project description:LncRNA and mRNA expression profiling of Hepatocellular carcinoma Huh7 when HINT1 knockdown. HINT1 is a novel tumor suppressor gene, which can regulate the transcription of a variety of cancer-related genes, and its regulation networks is poorly understood in hepatocellular carcinoma. We used the total RNA from siControl and siHINT1 Huh7 cells to analyze the differentially expressed lncRNA and mRNA which were regulated by HINT1, and further explored the ceRNA network that HINT1 may involved.

2022-03-09 | GSE177624 | GEO

Effects of UBE2S knockout on Huh7 cells

Project description:As the main type of primary liver cancer, hepatocellular carcinoma (HCC) seriously endangers human health. UBE2S is upregulated in human HCC tissue and associated with poor prognosis. To explore the biological functions and molecular mechanisms of UBE2S in HCC cells, we explored the effects of UBE2S knockout on Huh7 cells using RNA-seq.

2024-11-13 | GSE267607 | GEO

RNASeq of molecular basis of ancestral vertebrate electroreception

Project description:Elasmobranch fishes, including sharks, rays, and skates, use specialized electrosensory organs called Ampullae of Lorenzini to detect extremely small changes in environmental electric fields. Electrosensory cells within these ampullae are able to discriminate and respond to minute changes in environmental voltage gradients through an as-yet unknown mechanism. Here we show that the voltage-gated calcium channel CaV1.3 and big conductance calcium-activated potassium (BK) channel are preferentially expressed by electrosensory cells in little skate (Leucoraja erinacea) and functionally couple to mediate electrosensory cell membrane voltage oscillations, which are important in the detection of specific, weak electrical signals. Both channels exhibit unique properties compared with their mammalian orthologues to support electrosensory functions: structural adaptations in CaV1.3 mediate a low voltage threshold for activation, while alterations in BK support specifically tuned voltage oscillations. These findings reveal a molecular basis of electroreception and demonstrate how discrete evolutionary changes in ion channel structure facilitate sensory adaptation.

2017-03-01 | GSE93582 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data