Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cap 2’-O-ribose methylation is required for reward learning in Drosophila melanogaster

ABSTRACT: RNA-seq Quant-seq FWD performed on cap-adjacent methylatransferase mutants and wildtype of drosophila melanogaster.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE116212 | GEO | 2021/12/18

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Cap 2’-O-ribose methylation is required for reward learning in Drosophila melanogaster

Project description:Cap 2’-O-ribose methylation is required for reward learning in Drosophila melanogaster

| PRJNA477785 | ENA

LCL Bio-CAP-seq

Project description:LCL Bio-CAP-seq

| PRJNA795784 | ENA

Human senescence PRO-cap

Project description:Human senescence PRO-cap

| PRJNA658592 | ENA

PRO-cap in Drosophila melanogaster embryo at 3-4h and 6-8h after egg laying

Project description:Mapping of active transcription start sites using PRO-cap in whole-embryo at 3-4h and 6-8h AEL. Two biological replicates were performed at each time point.

2018-02-22 | E-MTAB-6154 | biostudies-arrayexpress

PRO-cap in Drosophila melanogaster embryo at 3-4h and 6-8h after egg laying

Project description:PRO-cap in Drosophila melanogaster embryo at 3-4h and 6-8h after egg laying

| PRJEB25091 | ENA

Essential roles of RNA cap-proximal ribose methylation in mammalian embryonic development and fertility

Project description:Eukaryotic RNA pol II transcripts are capped at the 5′ end by the methylated guanosine (m7G) moiety. In higher eukaryotes, CMTR1 and CMTR2 catalyse cap-proximal ribose methylations on the first (cap1) and second (cap2) nucleotides, respectively. These modifications mark RNAs as ‘self’, blocking the activation of the innate immune response pathway. Here we show that loss of mouse Cmtr1 or Cmtr2 leads to embryonic lethality, with non-overlapping sets of transcripts being regulated, without activation of the interferon pathway. In contrast, Cmtr1 mutant adult mouse livers exhibit a chronic activation of the interferon pathway, with multiple interferon-stimulated genes (ISGs) being expressed. Conditional deletion of Cmtr1 in the male germline leads to infertility, while global translation is unaffected in the Cmtr1 mutant mouse liver and human cells. Thus, mammalian cap1 and cap2 modifications have an essential role in embryonic gene regulation that is independent of their established role in evading the innate immune system.

2023-07-14 | GSE235348 | GEO

RNA-seq in NT, CAP-D3, and CAP-H2 expressing cells treated with DMSO or menadione

Project description:The goal of this experiment was to identify transcripts that are differentially expressed in CAP-D3 and CAP-H2 depleted cells with and without exposure to menadione

2019-10-30 | GSE139540 | GEO

Propionibacterium phage CAP-1

Project description:Propionibacterium phage CAP-1 Genome sequencing

| PRJNA953785 | ENA

Rhodococcus sp. CAP-R1

Project description:Rhodococcus sp. CAP-R1 Genome sequencing

| PRJNA728392 | ENA

Influence of CAP-D3 in Arabidopsis thaliana transcription

Project description:Transcriptome analysis of two different mutants of the condensin II subunit CAP-D3. Four week-old plantlets from the T-DNA insertion lines SAIL_826_B06 (cap-d3 SAIL) and SALK_094776 (cap-d3 SALK) were compared to Col-0 wild-type plants.

2020-12-31 | E-MTAB-8969 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data