Towards minimal residual disease-directed therapy in melanoma
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ABSTRACT: Many patients with advanced cancers achieve dramatic responses to a panoply of therapeutics, yet retain minimal residual disease (MRD), which ultimately results in relapse. To gain insights into the biology of MRD we applied single-cell RNA-sequencing to malignant cells isolated from BRAF-mutant patient-derived xenograft (PDX) melanoma cohorts exposed to concurrent RAF/MEK-inhibition.
ORGANISM(S): Homo sapiens
PROVIDER: GSE116237 | GEO | 2018/07/18
REPOSITORIES: GEO
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