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Endothelial Cell CD36 Optimizes Tissue Fatty Acid Uptake

ABSTRACT: Movement of circulating fatty acids (FAs) to parenchymal cells requires their transfer across the endothelial cell (EC) barrier. The multi-ligand receptor cluster of differentiation 36 (CD36) facilitates tissue FA uptake and is expressed in ECs and parenchymal cells such as myocytes and adipocytes. Whether tissue uptake of FAs is dependent on EC or parenchymal cell CD36, or both, is unknown. Using a cell-specific deletion approach, we show that CD36-mediated FA transport across ECs rate-limits tissue FA uptake, and its loss leads to metabolic effects in parenchymal cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE116350 | GEO | 2018/06/28

REPOSITORIES: GEO

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