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Single-cell RNA-seq of sorted CD8+ T cells from B16 melanoma tumors

ABSTRACT: CD8 T cells are the main effectors of the adaptive immune response against intracellular pathogens and cancer. Chronic antigen stimulation and inflammation lead to CD8 T cell differentiation and function that differ from those generated during acute infections. A comprehensive definition of the heterogeneity existing within both tumor-specific and total CD8 tumor-infiltrating T cells remains to be clearly established. To investigate this heterogeneity at the transcriptomic level, we performed paired single-cell RNA and TCR sequencing of >3500 CD8 T cells infiltrating B16 murine melanoma tumors, including cells of known tumor-specificity.

ORGANISM(S): Mus musculus

PROVIDER: GSE116390 | GEO | 2019/10/10

REPOSITORIES: GEO

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