Transcriptomics

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Newly identified Aspergillus nidulans PKA targets play a role in carbon-catabolite repression


ABSTRACT: A transcriptomic assessment of a kinase deletion mutant (ΔpkaA) and a control strain revealed many cellular activities this kinase is impacting. Studies were conducted in the model filamentous fungi, Aspergillus nidulans¸ under rich growth conditions. PkaA is a known kinase that mediates a wide range of processes including: nutrient sensing, stress responses, regulation of metabolism, as well as development and pathogenicity. Here, fungi were grown in rich media containing glucose. The comparison between the control strain and the deletion mutant transcript levels revealed previously unknown targets, such as the transcription factor CreA, the main repressor responsible for carbon catabolite repression (CCR).

ORGANISM(S): Aspergillus nidulans

PROVIDER: GSE116579 | GEO | 2018/07/04

REPOSITORIES: GEO

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