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Circulating miRNA profile of MMTV-NeuT mouse model of spontaneous mammary carcinogenesis.

ABSTRACT: We investigated, in a spontaneous mouse model of breast carcinogenesis (MMTV/NeuT), the modifications in the level of circulating miRNAs during different stages of disease, from early dysplastic stage to overt carcinoma, and their correlation with the pathological stage of the primary mammary lesions.

ORGANISM(S): Mus musculus

PROVIDER: GSE117000 | GEO | 2019/12/03

REPOSITORIES: GEO

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Gene expression profile of bone marrow from MMTV-NeuT mouse model of spontaneous mammary carcinogenesis.

Project description:We investigated, in a spontaneous mouse model of breast carcinogenesis (MMTV/NeuT), the modifications in the hematopoietic and stromal bone marrow (BM) compartments and their correlation with the pathological stage of the primary mammary lesions, following the idea that signs of the cross-talk between the BM and elements located in the tumor microenvironment, either neoplastic or stroma/immune cells, can be identified in the very early phases of cancer development, and lead to the instruction of a tumor-promoting hematopoiesis.

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Gene expression profile of bone marrow and circulating miRNA profile from MMTV-NeuT mouse model of spontaneous mammary carcinogenesis.

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Role of endogenous type I Interferon in spontaneous, Her2/Neu oncogene-driven carcinogenesis

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DIMETHYLBENZANTHRACENE (DMBA) INDUCED MAMMARY CARCINOGENESIS IN MMTV-Neu and MMTV/p53 KO FEMALE MICE AND EFFECTS OF REXINOIDS

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