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Addressing the repertoire of T helper Cells in the context of myocardial infarction

ABSTRACT: T-cells can influence the post-myocardial infarction healing process. The fundamental role of T cells in adaptive immunity relies mainly on a diverse repertoire of T cell receptor (TCR) α and β chains that display unique antigen specificities. Thus, we performed high-throughput sequencing of the TCRβ chains on CD4+ T cells purified by fluorescence-activated cell sorting (FACS) from the heart and med-LNs of MI and sham-operated mice as an unbiased approach to screen for MI-related TCR signatures.

ORGANISM(S): Mus musculus

PROVIDER: GSE117076 | GEO | 2019/08/14

REPOSITORIES: GEO

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Gene expression profile of myosin-specific CD4+ T-cells activated after myocardial infarction

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