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YAP activation mediates acquired resistance to ALK inhibitor in ALK rearranged non–small cell lung cancer

ABSTRACT: To investigate a possible candidate for overcoming the acquired resistance to ALK-TKI, we established an in vitro model of acquired resistance to crizotinib (H3122-CR) by exposing EML4-ALK–positive H3122 lung cancer cells to increasing doses of crizotinib.

ORGANISM(S): Homo sapiens

PROVIDER: GSE117181 | GEO | 2019/12/31

REPOSITORIES: GEO

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