Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Unique regulation of cis-regulatory elements facilitates reacquisition of pluripotency

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE117205 | GEO | 2019/09/19

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Unique regulation of cis-regulatory elements facilitates reacquisition of pluripotency [RNA-seq]

Project description:Ectopic expression of selected transcription factors enables reprogramming of somatic cells to pluripotency. Despite steady progress in the field the exact molecular mechanisms that coordinate this remarkable transition remain still largely elusive. To better understand the final steps during the acquisition of pluripotency, we optimized an experimental system where cells exit pluripotency and then are systematically challenged to reacquire pluripotency. Using this approach we identify a transient period of deterministic reprogramming during which cells exposed to ectopic transcription factors, but not serum/LIF alone, revert to pluripotency with near 100% efficiency before approaching somatic kinetics (1-2 weeks) and efficiencies (1-2%). Investigation of the transient phase reveals unique molecular dynamics that point to a set of cis-regulatory elements that appear central to facilitating reprogramming. Interestingly, these regions retain an epigenetic signature during in vitro and in vivo differentiation and may act as primary targets of ectopically induced factors during somatic cell reprogramming.

2019-09-19 | GSE117204 | GEO

Unique regulation of cis-regulatory elements facilitates reacquisition of pluripotency [ChIP-seq]

2019-09-19 | GSE117203 | GEO

Unique regulation of cis-regulatory elements facilitates reacquisition of pluripotency [ATAC-seq]

2019-09-19 | GSE117202 | GEO

Unique regulation of cis-regulatory elements facilitates reacquisition of pluripotency

Project description:Unique regulation of cis-regulatory elements facilitates reacquisition of pluripotency

| PRJNA481462 | ENA

Unique regulation of cis-regulatory elements facilitates reacquisition of pluripotency [ChIP-seq]

Project description:Unique regulation of cis-regulatory elements facilitates reacquisition of pluripotency [ChIP-seq]

| PRJNA481461 | ENA

Unique regulation of cis-regulatory elements facilitates reacquisition of pluripotency [ATAC-seq]

Project description:Unique regulation of cis-regulatory elements facilitates reacquisition of pluripotency [ATAC-seq]

| PRJNA481459 | ENA

Unique regulation of cis-regulatory elements facilitates reacquisition of pluripotency [RNA-seq]

Project description:Unique regulation of cis-regulatory elements facilitates reacquisition of pluripotency [RNA-seq]

| PRJNA481460 | ENA

High-throughput discovery of post-transcriptional cis-regulatory elements

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-03-04 | GSE75161 | GEO

Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-01-08 | GSE136565 | GEO

CRISPRi screen of prostate cancer associated risk cis-regulatory elements

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-12-16 | GSE142811 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data