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Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE117259 | GEO | 2018/09/17

REPOSITORIES: GEO

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Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation [ChIA-PET]

Project description:Transcription factor NF-κB regulates cellular responses to environmental cues. For many stimuli NF-κB resides only transiently in the nucleus. Consequently, time-dependent transcriptional outputs are a fundamental feature of NF-κB activation. Here we identify mechanisms that direct kinetic patterns of NF-κB-dependent gene expression and transcriptional outcomes in response to a transient NF-κB-inducing stimulus in B cells. By combining RELA binding, RNA polymerase II (Pol II) recruitment, and perturbation of NF-κB activation, we demonstrate that kinetic differences amongst early- and late-activated RELA target genes can be understood based on chromatin configuration prior to cell activation and RELA-dependent priming, respectively. Additionally, we identified genes that were repressed by RELA activation and others that responded to RELA-activated transcription factors. Cumulatively, our studies define an NF-κB-responsive inducible gene cascade in activated B cells.

2018-09-17 | GSE117241 | GEO

Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation [RNA-seq]

2018-09-17 | GSE117254 | GEO

Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation [ChIP-seq]

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Transcriptional outcomes and kinetic patterning of gene expression in response to NF-?B activation.

Project description:Transcription factor nuclear factor kappa B (NF-?B) regulates cellular responses to environmental cues. Many stimuli induce NF-?B transiently, making time-dependent transcriptional outputs a fundamental feature of NF-?B activation. Here we show that NF-?B target genes have distinct kinetic patterns in activated B lymphoma cells. By combining RELA binding, RNA polymerase II (Pol II) recruitment, and perturbation of NF-?B activation, we demonstrate that kinetic differences amongst early- and late-activated RELA target genes can be understood based on chromatin configuration prior to cell activation and RELA-dependent priming, respectively. We also identified genes that were repressed by RELA activation and others that responded to RELA-activated transcription factors. Cumulatively, our studies define an NF-?B-responsive inducible gene cascade in activated B cells.

| S-EPMC6147668 | biostudies-literature

Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation

Project description:Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation

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Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation [ChIA-PET]

Project description:Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation [ChIA-PET]

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Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation [ChIP-seq]

Project description:Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation [ChIP-seq]

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Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation [RNA-seq]

Project description:Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation [RNA-seq]

| PRJNA481546 | ENA

NF-κB activation impairs somatic cell reprogramming in ageing

Project description:This SuperSeries is composed of the SubSeries listed below.

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An NF-κB-dependent, lineage-specific transcriptional program regulates Treg identity and function

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