Genomics

Dataset Information

0

Genome-wide maps of chromatin state in primary MLL-AF9 AML


ABSTRACT: Here we describe the development of CKIα inhibitors, which co-target the transcriptional kinases CDK7 and CDK9, thereby augmenting CKIα-induced p53 activation and its anti-leukemic activity. Oncogene-driving super-enhancers (SEs) are highly sensitive to CDK7/9 inhibition. We identified multiple newly-gained SEs in primary mouse AML cells and demonstrate that the inhibitors abolish many SEs and preferentially suppress the transcription elongation of SE-driven oncogenes. We show that blocking CKIα together CDK7 and/or CDK9 synergistically stabilize p53, deprive leukemia cells of survival and proliferation-maintaining SE-driven oncogenes, and induce apoptosis.

ORGANISM(S): Mus musculus

PROVIDER: GSE117443 | GEO | 2018/08/23

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2017-10-23 | GSE75814 | GEO
2017-10-23 | GSE75810 | GEO
2020-05-16 | GSE146714 | GEO
2020-05-16 | GSE141280 | GEO
2020-05-16 | GSE141279 | GEO
2021-10-04 | GSE185024 | GEO
2021-10-04 | GSE185003 | GEO
2020-05-26 | PXD010193 | Pride
2024-05-16 | GSE266389 | GEO
2024-05-16 | GSE266386 | GEO