Genomics

Dataset Information

0

Autophagy Suppresses CD8+ T cell Anti-tumour Immunity


ABSTRACT: Here we demonstrate that inactivation of the essential autophagy genes, Atg5, Atg14, or Atg16L1 results in tumour rejection. Despite a significant reduction in the total number of CD8+ tumour infiltrating lymphocytes (TILs), loss of Atg5 causes a profound shift toward IFNg and TNF producing effector memory cells. Consistent with this, adoptive transfer with Atg5-/- T cells promotes tumour control. Mechanistically, CD8+ T cells lacking autophagy exhibit enhanced glucose metabolism resulting in global changes in histone trimethylation and increased transcriptional activation of effector target genes. Restricting glucose is sufficient to suppress autophagy-dependent increases in effector function and reverse alterations in histone trimethylation. These findings identify autophagy as a cell-autonomous negative regulator of CD8+ T cell anti-tumour immunity with implications on T cell-based immunotherapy.

ORGANISM(S): Mus musculus

PROVIDER: GSE117757 | GEO | 2019/04/09

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2008-11-15 | E-GEOD-13512 | biostudies-arrayexpress
2008-11-08 | GSE13512 | GEO
2023-02-28 | GSE197354 | GEO
2020-02-27 | GSE139573 | GEO
2015-04-15 | E-GEOD-67881 | biostudies-arrayexpress
2015-04-23 | E-GEOD-49254 | biostudies-arrayexpress
2015-09-18 | E-GEOD-73158 | biostudies-arrayexpress
2023-01-12 | GSE193568 | GEO
2023-11-21 | GSE245134 | GEO
2011-11-21 | E-MTAB-880 | biostudies-arrayexpress