Gene expression profile of U2-OS control and NSD3 knockdown cells

ABSTRACT: Osteosarcomas (OS) have highly chaotic genomes, yet their cancer drivers are poorly defined. Leveraging cross-species OS genomics we identify the frequent amplification of NSD3, a histone lysine methyltransferase and expose the NSD3-ARID3A axis as a core pathway in osteosarcomagenesis. Loss- and gain-of-function studies with CRISPR-Cas9 and lentivirus systems establish the causal role of NSD3 in OS tumor growth and spontaneous metastasis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE118129 | GEO | 2021/08/03

REPOSITORIES: GEO