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RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Tetrahymena thermophila

PROVIDER: GSE118200 | GEO | 2019/02/28

REPOSITORIES: GEO

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RNAi-dependent <i>Polycomb</i> repression controls transposable elements in <i>Tetrahymena</i>.

Project description:RNAi and Polycomb repression play evolutionarily conserved and often coordinated roles in transcriptional silencing. Here, we show that, in the protozoan Tetrahymena thermophila, germline-specific internally eliminated sequences (IESs)-many related to transposable elements (TEs)-become transcriptionally activated in mutants deficient in the RNAi-dependent Polycomb repression pathway. Germline TE mobilization also dramatically increases in these mutants. The transition from noncoding RNA (ncRNA) to mRNA production accompanies transcriptional activation of TE-related sequences and vice versa for transcriptional silencing. The balance between ncRNA and mRNA production is potentially affected by cotranscriptional processing as well as RNAi and Polycomb repression. We posit that interplay between RNAi and Polycomb repression is a widely conserved phenomenon, whose ancestral role is epigenetic silencing of TEs.

| S-EPMC6411011 | biostudies-literature

RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena [RNA-seq]

Project description:RNA interference (RNAi) and Polycomb repression play evolutionarily conserved and often coordinated roles in transcriptional silencing. Here we show that in the protozoan Tetrahymena thermophila, germ line-specific internally eliminated sequences (IES) - many related to transposable elements (TE) - are transcriptionally activated in mutants deficient in the RNAi-dependent Polycomb repression pathway. Mobilization of recently duplicated TE also dramatically increases in these mutants. Importantly, transcriptional silencing and activation of TE-related sequences are accompanied by switching between noncoding RNA (ncRNA) and mRNA production, which can be affected by co-transcriptional processing as well as RNAi and Polycomb repression. We posit that interplay between RNAi and Polycomb repression is a widespread phenomenon, whose ancestral role is epigenetic silencing of TE.

2019-03-01 | GSE118199 | GEO

RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena [small RNA-seq]

Project description:RNA interference (RNAi) and Polycomb repression play evolutionarily conserved and often coordinated roles in transcriptional silencing. Here we show that in the protozoan Tetrahymena thermophila, germ line-specific internally eliminated sequences (IES)—many related to transposable elements (TE)—are transcriptionally activated in mutants deficient in the RNAi-dependent Polycomb repression pathway. Mobilization of recently duplicated TE also dramatically increases in these mutants. Importantly, transcriptional silencing and activation of TE-related sequences are accompanied by switching between noncoding RNA (ncRNA) and mRNA production, which can be affected by co-transcriptional processing as well as RNAi and Polycomb repression. We posit that interplay between RNAi and Polycomb repression is a widespread phenomenon, whose ancestral role is epigenetic silencing of TE.

2019-03-01 | GSE118198 | GEO

RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena

Project description:RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena

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RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena [RNA-seq]

Project description:RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena [RNA-seq]

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An RNAi-dependent Polycomb Repression Pathway Is Required for Co-transcriptional Silencing of Transposable Elements

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-12-31 | GSE64064 | GEO

RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena [small RNA-seq]

Project description:RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena [small RNA-seq]

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An RNAi-dependent Polycomb Repression Pathway Is Required for Co-transcriptional Silencing of Transposable Elements

Project description:An RNAi-dependent Polycomb Repression Pathway Is Required for Co-transcriptional Silencing of Transposable Elements

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Separable roles for RNAi in regulation of transposable elements and viability in the fission yeast Schizosaccharomyces japonicus

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-02-17 | GSE185665 | GEO

Analyses of RNAi-heterochromatin positive feedback loop in Tetrahymena

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-03-06 | GSE87015 | GEO

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