Transcriptomics

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IL­1b signaling in human coronary artery endothelial cells


ABSTRACT: IL­1b signaling is critically involved in inflammatory diseases. However, the gene targets and mechanisms of IL­1b mediated inflammatory processes in adult human vascular endothelium still remain unclear. We show that IL­1b regulates genes coding for inflammatory cytokines, cell adhesion molecules and pathways through NFkB transcriptional activation. We further identify the genes regulated by IL­1b that regulate endothelial barrier function and act as targets for known clinically relevant compunds. These findings stimulate further research to identify novel signaling mechanisms modulating endothelial barrier function in IL­1b driven inflammatory pathologies.

ORGANISM(S): Homo sapiens

PROVIDER: GSE118297 | GEO | 2019/05/15

REPOSITORIES: GEO

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