Transcriptomics

Dataset Information

0

Rapid CLIP Dissociation from MHC II Promotes an Unusual Antigen Presentation Pathway in Autoimmunity


ABSTRACT: A number of autoimmunity-associated MHC class II proteins interact only weakly with the invariant chain-derived class II-associated invariant chain peptide (CLIP). CLIP dissociates rapidly from I-Ag7 even in the absence of DM, and this property is related to the type 1 diabetes-associated b57 polymorphism. We generated knock-in Non-obese Diabetic (NOD) mice with a single amino acid change in the CLIP segment of invariant chain in order to moderately slow CLIP dissociation from I-Ag7. These knock-in mice had a significantly reduced incidence of spontaneous type 1 diabetes and diminished islet infiltration by CD4 T cells, in particular T cells specific for fusion peptides generated by covalent linkage of proteolytic fragments within b cell secretory granules. Rapid CLIP dissociation enhanced presentation of such extracellular peptides, thus bypassing the conventional MHC class II antigen processing pathway. Autoimmunity-associated MHC class II polymorphisms therefore not only modify binding of self-peptides, but also alter the biochemistry of peptide acquisition.

ORGANISM(S): Mus musculus

PROVIDER: GSE118322 | GEO | 2018/08/09

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-08-13 | GSE265793 | GEO
2024-08-13 | GSE214855 | GEO
| PRJNA485179 | ENA
2015-10-12 | PXD001934 | Pride
2020-06-15 | GSE151070 | GEO
2020-01-08 | E-MTAB-8057 | biostudies-arrayexpress
2023-12-29 | GSE229921 | GEO
2023-12-18 | GSE246253 | GEO
2021-03-26 | PXD024400 | Pride
2019-10-31 | GSE118568 | GEO